About this product
Medicube Zero Melanin Serum is a concentrated brightening treatment that targets hyperpigmentation at multiple pathways simultaneously. It combines tranexamic acid, alpha arbutin, niacinamide, and ascorbyl glucoside to inhibit melanin synthesis, suppress tyrosinase activity, and reduce the appearance of existing dark spots. Suitable for post-acne marks, sun damage, and uneven skin tone.
Best for all skin looking to address hyperpigmentation, dark spots, post-acne marks — with a focus on brightening.
Product Attributes
pH Level
Mildly acidic — close to skin's natural pH (4.5–5.5). Generally well tolerated.
How to Use
- 1After cleansing and toning, apply 2–3 drops to the face.
- 2Press gently into skin, focusing on problem areas.
- 3Layer with moisturiser.
- 4Always apply SPF 30+ in the morning when using brightening actives.
Dermatologist Note
Tranexamic acid (TXA) works by blocking plasmin-keratinocyte interactions that trigger UV-induced melanogenesis — a mechanism distinct from classic tyrosinase inhibitors like arbutin. Clinical trials show 3% TXA achieves comparable depigmentation to hydroquinone 3% with a superior safety profile (Na et al., 2013). Combining TXA with niacinamide and arbutin addresses melanin production, transfer, and oxidation simultaneously.
Based on published clinical literature and dermatological research.
Ingredient Analysis
Full Ingredient List (INCI)
6 ingredientsListed in order of concentration (highest first)
Tranexamic Acid, Alpha Arbutin, Niacinamide, Ascorbyl Glucoside, Hyaluronic Acid, Panthenol
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